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B6.Cg-Tg(Arc-cre/ERT2)MRhn/CdnyJ
Cat. No.: CEMM-07250469
These mice express Cre-ERT2 under the direction of the activity regulated cytoskeletal-associated protein (Arc) promoter/enhancer regions. They are useful in comparing activation of neuronal populations in the hippocampus during encoding and retrieval of memory.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(Arc-cre/ERT2)MRhn
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| Allele Name |
transgene insertion M
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Tg(Arc-cre/ERT2)MRhn
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| Gene Name |
transgene insertion M
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| Chromosome |
UN
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| Expressed Genes |
cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
Hippocampus.
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| Strain of Origin |
C57BL/6J x CBA
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| Molecular Note |
Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a BAC containing the entire mouse activity regulated cytoskeletal-associated protein (Arc) gene. A CreERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand-binding domain), followed by an SV40 polyadenylation sequence, was inserted into the translation initiation site of the gene. Founder lines M and F were established and maintained.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Noncarrier
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| Breeding Considerations |
When maintaining a live colony, hemizygous mice may be bred to wildtype (non-carrier) mice from the colony or to C57BL/6J inbred mice.
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| Breeding Strategy |
Hemizygote x Noncarrier; Noncarrier x Hemizygote
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For Research Use Only.
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