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STOCK Tg(En2-cre)22Alj/J
Cat. No.: CEMM-07250137
These En2-cre line 22 transgenic mice (also called En2cre-22, En2cre line Tg22, or En2-cre tg-22) have the mouse engrailed 2 (En2) promoter/enhancer elements directing expression of Cre recombinase to a subset of En2-expressing cells; including the embryonic midbrain-hindbrain (mesencephalon-metencephalon) constriction region of the developing brain that gives rise to the posterior midbrain and medial cerebellum.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(En2-cre)22Alj
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| Allele Name |
transgene insertion 22
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Tg(En2-cre)22Alj
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| Gene Name |
transgene insertion 22
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| Chromosome |
UN
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
The En2 promoter directs expression in the embryonic midbrain-hindbrain constriction region, the cerebellum, tectum, hippocampus and tegmentum.
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| Strain of Origin |
CD-1
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| Molecular Note |
The transgenic constuct contained a Cre recombinase gene adjoined to an En2 minimal promoter and enhancer. The En2 promoter directs expression in the embryonic midbrain-hindbrain constriction region, the cerebellum, tectum, hippocampus and tegmentum.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Noncarrier
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| Breeding Considerations |
When maintaining a live colony, hemizygous mice may be bred to non-carrier (wildtype) siblings. The donating investigator has not determined the phenotype of homozygous mice to date.
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For Research Use Only.
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