Mouse Models

Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.

For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.

Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.

If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.

Our Mouse Models

Reporter Mouse

Floxed Mouse

Recombinase-expressing Mouse

Inducible Mouse

B6.129S4(SJL)-Crhr2^{tm1.1(cre)Lbrl}/J (Cat. No.: CEMM-07250960)		Inquiry
Crhr2-ires-Cre knock-in mice express Cre recombinase under the direction of the Crhr2 promoter in nodose ganglia of vagal sensory neurons. show more close

B6(Cg)-Zfp24^tm1.1Pop/J (Cat. No.: CEMM-07250709)		Inquiry
Zfp191flox mice possess loxP sites flanking exons 2-3 of the zinc finger protein 24 (Zfp24) gene. This strain may be useful for studying the function of myelinating oligodendrocytes. show more close

B6J.Cg-Vip^tm1(cre)Zjh/AreckJ (Cat. No.: CEMM-07250883)		Inquiry
Vip-IRES-Cre mice have Cre recombinase expression directed to Vip-expressing cells by the endogenous promoter/enhancer elements of the vasoactive intestinal polypeptide locus. Cre activity is detected in the neocortex, hippocampus, olfactory bulb, suprachiasmatic nuclei, and other discrete midbrain and brainstem regions. These mice may be useful to study neural GABAergic circuits throughout the mammalian brain. While Vip-IRES-Cre was designed to retain endogenous Vip expression, a 2019 publication indicates this allele has reduced Vip expression - see details below. As such, researchers may use homozygous mice for routine colony maintenance, but should consider using heterozygous Vip-IRES-Cre mice and wildtype littermate controls in all their studies. is a C57BL/6J-congenic Vip-IRES-Cre knock-in mouse line, called Vip-IRES-Cre (C57BL/6J) or B6J.Vip-IRES-Cre. show more close

B6N(129S4)-Setbp1^{tm1c(EUCOMM)Wtsi}/LutzyMmjax (Cat. No.: CEMM-07250935)		Inquiry
Exon 4 of the Setbp1 (SET binding protein 1) gene is flanked by loxP sites in this conditional mutant strain. These mice may be useful in studies of SETBP1 disorder and Schinzel-Giedion midface retraction syndrome. show more close

B6;129S-Rap1a^tm1Morz Rap1b^tm1Morz/J (Cat. No.: CEMM-07250434)		Inquiry
These Rap1 double floxed mice possess loxP sites flanking exons in the RAP-related protein (Rap)-1a (Rap1a) and -1b (Rap1b) genes. This strain may be useful for studying synaptic plasticity and changes in cortical inputs to the lateral amygdala. show more close

B6.129(C)-Cd19^tm1(cre)Cgn Is(14)2Rdf/CjwuJ (Cat. No.: CEMM-07251091)		Inquiry
MDRCD19 double mutant mice contain the 14qC3-MDR allele, containing a loxP- and frt-flanked region on Chr 14 that has been implicated in B cell chronic lymphocytic leukemia (CLL). They also contain a Cd19cre allele with cre expression in B-lymphocytes during development and differentiation. When bred to MDRCas9 double homozygous mice, these mice have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia. show more close

*B6.129-Gt(ROSA)26Sor^{tm1(CAG-cas9, -EGFP)Fezh} Is(14)2Rdf/CjwuJ** (Cat. No.: CEMM-07251092)		Inquiry
MDRCas9 double mutant mice contain the 14qC3-MDR allele, containing a loxP- and frt-flanked region on Chr 14 that has been implicated in B cell chronic lymphocytic leukemia (CLL). They also contain a Rosa26-LSL-Cas9 knock-in allele with cre recombinase-dependent expression of CRISPR associated protein 9 (cas9) endonuclease and EGFP directed by a CAG promoter. When bred to MDRCD19 double homozygous mice, these mice have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia. show more close

B6.129P2-Mecp2^tm2Bird/J (Cat. No.: CEMM-07250060)		Inquiry
Mice with this X-linked lox-STOP mutation of the methyl CpG binding protein 2 gene may be useful in neurological and developmental studies of Rett syndrome and its amelioration upon excision of the lox-STOP cassette. show more close

C57BL/6J-Tg(ACTB-NOTCH1)1Shn/J (Cat. No.: CEMM-07250053)		Inquiry
These mutant mice contain a "Lox-STOP-Lox" cassette that prevents expression of the human NOTCH1 transgene until excised by Cre-recombinase. This strain may be useful for generating conditional mutations in applications related to the study of notch signaling during apoptotic cell death. show more close

*C57BL/6-Tg(ACTB-MAP2K1K97M)1Stl/J** (Cat. No.: CEMM-07250057)		Inquiry
These mutant mice possess a Lox-STOP-Lox cassette controlling the inserted human dominant-negative mutant form of human MEK1. This strain may be useful for generating conditional mutations in studies involving synaptic plasticity and memory. show more close

For Research Use Only.