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B6;129S-Rap1atm1Morz Rap1btm1Morz/J
Cat. No.: CEMM-07250434
These Rap1 double floxed mice possess loxP sites flanking exons in the RAP-related protein (Rap)-1a (Rap1a) and -1b (Rap1b) genes. This strain may be useful for studying synaptic plasticity and changes in cortical inputs to the lateral amygdala.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rap1atm1Morz
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Rap1a
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| Gene Name |
RAS-related protein 1a
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| Chromosome |
3
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| MGI Accession ID | show more close |
| Strain of Origin |
129S/SvEv
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| Molecular Note |
A loxP site was inserted upstream of exon 2 and a loxP-flanked neomycin selection cassette was inserted downstream of exon 3. Transient expression of Cre recombinase removed the neomycin cassette, leaving exons 2 and 3 flanked by loxP sites. Correct targeting was confirmed through Southern blots.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
When maintaining a live colony, double homozygous mice may be bred together.
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For Research Use Only.
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