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B6.129(C)-Cd19tm1(cre)Cgn Is(14)2Rdf/CjwuJ

Cat. No.: CEMM-07251091

Common Name: MDRCD19
MDRCD19 double mutant mice contain the 14qC3-MDR allele, containing a loxP- and frt-flanked region on Chr 14 that has been implicated in B cell chronic lymphocytic leukemia (CLL). They also contain a Cd19cre allele with cre expression in B-lymphocytes during development and differentiation. When bred to MDRCas9 double homozygous mice, these mice have applications in studies related to tumorigenesis and therapeutic management of chronic lymphocytic leukemia.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Cd19tm1(cre)Cgn
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Allele Name
targeted mutation 1
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Allele Attributes
Recombinase-expressing
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Gene Symbol
Cd19
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Gene Name
CD19 antigen
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Chromosome
7
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Expressed Genes
Cre, Cre recombinase, bacteriophage P1
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MGI Accession ID
1931143
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Site of Expression
B cells
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Strain of Origin
129P2/OlaHsd
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Molecular Note
In frame insertion of a Cre recombinase gene into the first coding exon followed by an FRT flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses Cre recombinase specifically in B lineage cells throughout development.
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HUSBANDRY
Suggested Controls
B6.129P2
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Breeding Considerations
When maintaining a live colony, double homozygous mice may be bred together.
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Breeding Strategy
Heterozygous for Cd19 Heterozygous for Is(14)2Rdf x Heterozygous for Cd19 Heterozygous for Is(14)2Rdf
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For Research Use Only.
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