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B6N(129S4)-Setbp1tm1c(EUCOMM)Wtsi/LutzyMmjax
Cat. No.: CEMM-07250935
Exon 4 of the Setbp1 (SET binding protein 1) gene is flanked by loxP sites in this conditional mutant strain. These mice may be useful in studies of SETBP1 disorder and Schinzel-Giedion midface retraction syndrome.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Setbp1tm1c(EUCOMM)Wtsi
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| Allele Name |
targeted mutation 1c
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Setbp1
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| Gene Name |
SET binding protein 1
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| Chromosome |
18
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N-Atm1Brd
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| Molecular Note |
The construct incorporates an FRT lacZ-loxP followed by a neomycin resistance cassette, SV40 polyA, a second FRT site and a second loxP site in intron 3. A third loxP site is inserted downstream in intron 5 (position 78855613). Flp-mediated recombination removed the FRT flanked lacZ and neo cassette leaving exon 4 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
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| Breeding Considerations |
When maintaining a live colony, both homozygous and heterozygous mice may be bred.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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