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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Rims2tm1.1Sud/J (Cat. No.: CEMM-07250298) | Inquiry | |
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This floxed Rims2 (regulating synaptic membrane exocytosis 2) mutation strain enables cre-mediated excision of the α, β, and γ isoforms of the gene and may be useful in studies of synaptic neurotransmission.
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| B6;129-Dlg3tm1Rlh/J (Cat. No.: CEMM-07250262) | Inquiry | |
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When crossed with a Cre recombinase-expressing strain, this floxed Dlg3 (discs, large homolog 3 (Drosophila); SAP102) strain is useful in eliminating tissue-specific expression of the gene. Defective expression of this gene is associated with deficits in synaptic plasticity and deterioration of learning/memory functions.
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| B6.129-Mgat1tm2Jxm/J (Cat. No.: CEMM-07250061) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking the single coding exon of the Mgat1 gene. This strain may be useful for generating conditional mutations in applications related to fertilization and embryonic development.
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| B6;129-Nefltm1(cre/ERT)Nat/J (Cat. No.: CEMM-07250104) | Inquiry | |
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These targeted mutation mice carry a tamoxifen-inducible Cre cassette knocked into the 3' UTR of the Nefl, neurofilament, light polypeptide gene. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating 4-hydroxytamoxifen-induced, Cre-mediated targeted deletions specifically in large neurons.
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| B6.Cg-Clocktm1Jt/J (Cat. No.: CEMM-07250305) | Inquiry | |
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Homozygous mice carrying this loxP-flanked stop-tetO cassette inserted into Clock (circadian locomotor output cycles kaput) lack expression of the endogenous gene. Crosses with a Cre strain or tTA transgenic animal should enable conditional restoration of expression.
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| 129S-Trpa1tm2Kykw/J (Cat. No.: CEMM-07250124) | Inquiry | |
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These mice possess loxP sites on either side of the S5/S6 transmembrane domains of the transient receptor potential cation channel, subfamily A, member 1 gene. When bred to mice with a cre recombinase gene, the S5/S6 transmembrane domains of the targeted gene are deleted in the cre-expressing tissues. This strain may be useful in functional studies of cation channels.
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| B6;CBA-Tg(Fgfr3-icre/ERT2)4-2Wdr/J (Cat. No.: CEMM-07250578) | Inquiry | |
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Fgfr3-icreERT2 mice express codon optimized iCreERT2 in forebrain subventricular zone progenitor cells and astrocytes making them useful for applications requiring tamoxifen-induced deletion of floxed sequences in these cells.
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| B6;CBA-Tg(Nkx2-1-icre/ERT2)1Kess/J (Cat. No.: CEMM-07250577) | Inquiry | |
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Nkx2-1-cre-ERT2 mice express codon optimized iCre-ERT2 in ventral forebrain precursor cells making them useful for applications requiring tamoxifen-induced deletion of floxed sequences in these cells.
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| B6;CBA-Tg(Sox10-cre)1Wdr/J (Cat. No.: CEMM-07250576) | Inquiry | |
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Sox10-Cre mice express Cre recombinase in the entire post-migratory post-otic neural crest population during early embryonic development.
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| STOCK Tg(Nkx6-2-icre)1Kess/SshiJ (Cat. No.: CEMM-07250643) | Inquiry | |
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Nkx6.2-Cre mice express codon optimized Cre recombinase, iCre, in neuroepithelial progenitor cells in the dorsal region of the medial ganglionic eminence (dMGE).
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For Research Use Only.