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B6.Cg-Clocktm1Jt/J
Cat. No.: CEMM-07250305
Homozygous mice carrying this loxP-flanked stop-tetO cassette inserted into Clock (circadian locomotor output cycles kaput) lack expression of the endogenous gene. Crosses with a Cre strain or tTA transgenic animal should enable conditional restoration of expression.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Clocktm1Jt
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Clock
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| Gene Name |
circadian locomotor output cycles kaput
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| Chromosome |
5
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| MGI Accession ID | show more close |
| Site of Expression |
Tissue specific promoters controlling transactivator protein (tTA) may be used to drive expression of Clock.
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| Strain of Origin |
129S7/SvEvBrd-Hprtb-m2 x C57BL/6Brd-Tyrc-Brd
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| Molecular Note |
A cassette containing loxP-stop-tetO-loxP was inserted at the 5' end of the Clock gene, proximal to exon 4 where the translation start site is located.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintained as a live colony, homozygous or heterozygous males may be bred with heterozygous females. Homozygous females do not breed well.
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For Research Use Only.
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