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129S-Trpa1tm2Kykw/J
Cat. No.: CEMM-07250124
These mice possess loxP sites on either side of the S5/S6 transmembrane domains of the transient receptor potential cation channel, subfamily A, member 1 gene. When bred to mice with a cre recombinase gene, the S5/S6 transmembrane domains of the targeted gene are deleted in the cre-expressing tissues. This strain may be useful in functional studies of cation channels.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Trpa1tm2Kykw
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Trpa1
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| Gene Name |
transient receptor potential cation channel
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
LoxP sites were placed on either side of exons 22-24 (encoding the S5/S6 transmembrane domains) and an FRT flanked neomycin resistance cassette inserted in the opposite transcriptional orientation in intron 24. The neomycin cassette was excised by crossing these mice to a Gt(ROSA)26Sor-driven Flp strain on a 129S4/SvJaeSor.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintained as a live colony, homozyogotes may be bred.
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For Research Use Only.
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