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STOCK Tg(Nkx6-2-icre)1Kess/SshiJ
Cat. No.: CEMM-07250643
Common Name: Nkx6.2-Cre
Nkx6.2-Cre mice express codon optimized Cre recombinase, iCre, in neuroepithelial progenitor cells in the dorsal region of the medial ganglionic eminence (dMGE).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(Nkx6-2-icre)1Kess
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| Allele Name |
transgene insertion 1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Tg(Nkx6-2-icre)1Kess
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| Gene Name |
transgene insertion 1
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| Chromosome |
UN
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Cre recombinase is expressed in progenitor cells in the dorsal region of the medial ganglionic eminence.
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| Strain of Origin |
(C57BL/6 x CBA)F1
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| Molecular Note |
A codon-improved Cre (iCre) containing a nuclear localization signal (nls) and an SV40 polyadenylation signal was fused to the initiation codon of the Nkx6-2 gene in a bacterial artificial chromosome (BAC). The construct was injected into fertilized oocytes.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Noncarrier
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| Breeding Considerations |
When maintaining a live colony hemizygous mice may be bred to wildtype (non-carrier) mice from the colony or to C57BL/6J. The donating investigator has not attempted to breed this strain to homozygosity. Occasional Cre expression is observed in the male germline resulting in germline recombination of floxed alleles when these are carried by the male parent.
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For Research Use Only.
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