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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J (Cat. No.: CEMM-07250131) | Inquiry | |
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This Trpa1CKO;pCAGGCre-ERTM compound mutant has a floxed allele of the Trpa1 (transient receptor potential cation channel, subfamily A, member 1) gene in addition to a tamoxifen inducible cre transgene driven by the chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer (see). Restricted to the cytoplasm, the cre/Esr1 protein can only gain access to the nuclear compartment after exposure to tamoxifen. Tamoxifen administration induces cre recombination within the Trpa1 allele, excising the S5/S6 transmembrane domains. Animals not treated with tamoxifen display no observable phenotype.
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| C57BL/6-Tg(Cck-cre)CKres/J (Cat. No.: CEMM-07250211) | Inquiry | |
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A minimal Cck (cholecystokinin) promoter drives expression of Cre in this transgenic strain. These mice express Cre at high levels in the brain cortex in a pattern that is qualitatively similar to that of the wildtype Cck gene. This strain may be useful for various psychiatric and neuroscience studies of this neuropeptide promoter.
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| B6;129S4-Olig1tm1(cre)Rth/J (Cat. No.: CEMM-07250214) | Inquiry | |
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In this targeted mutation strain, the mouse Olig1 (oligodendrocyte transcription factor 1) locus drives expression of cre in Olig1-expressing cells of the central nervous system (CNS).
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| STOCK Syt12tm1.1Sud/J (Cat. No.: CEMM-07250300) | Inquiry | |
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This Syt12 (synaptotagmin XII) mutant strain combines an S97A amino acid mutation with loxP sites that enable cre-mediated elimination of tissue-specific expression. This strain may be useful in studies of neurotransmission and the presynaptic function of Syt12 phosphorylation.
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| B6;129-Igs1tm1(CAG-Bgeo, -tdTomato/TEVP, -SV2B/GFP)Nat/J (Cat. No.: CEMM-07250184) | Inquiry | |
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A targeted insertion placed 2 kb 5' of the Igs1 (intergenic site, formerly Ubb) gene provides constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of Cre-mediated recombination. Following Cre-mediated recombination, the NLS-beta-geo coding region is excised and a downstream open reading frame is expressed. When Cre-mediated recombination occurs in neurons, the amino terminal piece (tdTomato/TEVP, a 6xmyc epitope, a TEVP cleavage site) labels all axon and dendrites, and the carboxy-terminal portion (SV2B, GFP, 3xHA epitope) labels presynaptic structures. This reporter can be activated by cre recombinase in any cell in the body at any time in development.
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| B6;129-Igs1tm3(CAG-Bgeo, -tdTomato/TEVP, -Dlg4, -GFP)Nat/J (Cat. No.: CEMM-07250229) | Inquiry | |
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A CMV/beta actin (Z/AP) promoter located 2 kb 5' of the Igs1 (intergenic site, formerly Ubb) gene drives constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of Cre-mediated recombination. When Cre-mediated recombination occurs in neurons, the amino terminal piece (tdTomato/TEVP, a 6xMyc epitope, a TEVP cleavage site) labels all axon and dendrites, and the carboxy-terminal portion (PSD95, GFP, 3xHA epitope) labels post-synaptic structures.
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| STOCK Olig2tm2(TVA, cre)Rth/J (Cat. No.: CEMM-07250213) | Inquiry | |
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In this targeted mutation strain, the mouse Olig2 (oligodendrocyte transcription factor 2) locus drives expression of cre and tva (an avian-specific retroviral receptor). This strain may be useful in studies of neurodevelopment.
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| B6;129-Vamp2tm1(cre/ERT)Nat/J (Cat. No.: CEMM-07250115) | Inquiry | |
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This creER knock-in line can be used to produce Vamp2 (vesicle-associated membrane protein 2) gene recombination in many diverse types of neurons following 4-hydroxytamoxifen treatment. Heterozygotes are normal in size and viability. Homozygotes of both genders have reduced viability.
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| B6;129P2-Gt(ROSA)26Sortm1(Trpv1, ECFP)Mde/J (Cat. No.: CEMM-07250112) | Inquiry | |
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A loxP-flanked neomycin cassette blocks expression of the rat Trpv1 (transient receptor potential cation channel, subfamily V, member 1) gene driven by the Gt(ROSA)26Sor gene in this targeted mutation/knock-in strain. Upon crossing to a tissue-specific Cre-expressing strain, TRPV1 and enhanced cyan fluorescent protein (ECFP) is expressed from the ROSA locus. Cells expressing TRPV1 are sensitive to capsaicin and similar chemical agonists. Treatment of mice or cells that have undergone Cre excision to remove the neomycin cassette can induce strong inward currents, trigger action potentials and activate stereotyped behaviors, allowing cell-type specific chemical genetic control of neuronal activity in vitro and in vivo. These mice may also be useful in studies of TCR signalling in T cells.
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| B6;129-Thtm1(cre/Esr1)Nat/J (Cat. No.: CEMM-07250116) | Inquiry | |
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These knock-in mice express a tamoxifen-inducible cre recombinase. When induced, cre activity is observed in dopaminergic neurons in the brain.
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For Research Use Only.