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B6;129S4-Olig1tm1(cre)Rth/J
Cat. No.: CEMM-07250214
In this targeted mutation strain, the mouse Olig1 (oligodendrocyte transcription factor 1) locus drives expression of cre in Olig1-expressing cells of the central nervous system (CNS).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Olig1tm1(cre)Rth
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Recombinase-expressing; Null/Knockout
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| Gene Symbol |
Olig1
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| Gene Name |
oligodendrocyte transcription factor 1
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| Chromosome |
16
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Cre expressed in Olig1-expressing cells of the central nervous system.
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| Strain of Origin |
129S4/SvJae
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| Molecular Note |
The majority of the coding region for this gene was replaced with a Cre-neo cassette via homologous recombination so that the Cre coding sequence is joined in-frame to the endogenous gene's coding region immediately following the translation initiation site. In situ hybridization of spinal cord from homozygous mutant embryos did not detect transcripts from the endogenous gene. In spinal cord from E10.5-E12.5 embryos heterozygous for this allele and for the conditional (Cre recombinase activated) lacZ reporter allele Gt(ROSA)26Sortm1Sor, Xgal staining co-localized with in situ hybridizing mRNAs for motor neuron and oligodendrocyte markers; antibodies to beta-galactosidase co-localized with those to an oligodendrocyte marker, but not to an astrocyte marker.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintained as a live colony, hemizygotes or homozygotes may be bred.
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For Research Use Only.
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