Online Inquiry
B6;129-Thtm1(cre/Esr1)Nat/J
Cat. No.: CEMM-07250116
Common Name: TH-IRES-creER
These knock-in mice express a tamoxifen-inducible cre recombinase. When induced, cre activity is observed in dopaminergic neurons in the brain.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Thtm1(cre/Esr1)Nat
show more
close
|
| Allele Name |
targeted mutation 1
show more
close
|
| Allele Attributes |
Recombinase-expressing; Inducible
show more
close
|
| Gene Symbol |
Th
show more
close
|
| Gene Name |
tyrosine hydroxylase
show more
close
|
| Chromosome |
7
show more
close
|
| Expressed Genes |
cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene
show more
close
|
| MGI Accession ID | show more close |
| Site of Expression |
When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given Tamoxifen, Cre expression is detected in a sparse number of dopaminergic neurons in the brain.
show more
close
|
| Strain of Origin |
129
show more
close
|
| Molecular Note |
An IRES-CreER cassette, a tetracycline resistance gene, and an FRT flanked neomycin selection marker were all knocked into the 3' UTR of the gene. The neomycin selection marker was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given tamoxifen, Cre expression was detected in a sparse number of dopaminergic neurons in the brain.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
show more
close
|
| Breeding Considerations |
When maintained as a live colony, heterozygotes or homozygotes may be bred.
show more
close
|
| Breeding Strategy |
Homozygote x Homozygote
show more
close
|
For Research Use Only.
Related Products