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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Rai1tm1Luo/J (Cat. No.: CEMM-07250714) | Inquiry | |
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The Rai1Tag knock-in allele expresses a FLAG/myc-tagged RAI1 (Rai1-Tag) before Cre recombinase exposure. Cre-mediated deletion of the floxed FLAG-myc-STOP sequence results in expression of RAI1/EGFP fusion protein (Rai1EGFP). These Rai1Tag may be useful for studying Rai1 DNA binding, circuit assembly and neuronal communication in human disorders such as Smith-Magenis syndrome (SMS).
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| B6;129S6-Gt(ROSA)26Sortm9(CAG-mCherry, -CHRM4*)Dym/J (Cat. No.: CEMM-07250710) | Inquiry | |
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The RC::FPDi dual-recombinase responsive allele has a frt-flanked STOP and loxP-flanked mCherry::STOP all preventing transcription of an HA-tagged hM4Di - a mutant G protein-coupled DREADD receptor that induces the canonical Gi/o pathway specifically following administration of its pharmacologically inert ligand (CNO). FLP recombinase results in mCherry fluorescence, and further exposure to Cre recombinase results in hM4Di expression in the overlapping populations. The RC::FPDi allele and its derivatives allow conditional intersectional genetics for chemogenetic studies to express an inhibitory DREADD that effectively induces membrane hyperpolarization and neuronal silencing.
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| B6;129S6-Gt(ROSA)26Sortm8(CAG-mCherry, -EGFP)Dym/J (Cat. No.: CEMM-07250736) | Inquiry | |
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The RC::FrePe dual-recombinase responsive fluorescent allele has a frt-flanked STOP and loxP-flanked mCherry::STOP all preventing transcription of eGFP. FLP recombinase results in mCherry fluorescence, and further exposure to Cre recombinase results in eGFP fluorescence in the overlapping populations. The RC::FrePe allele and its derivatives are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of two gene expression domains.
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| NOD/ShiLtJ-Gt(ROSA)26Sorem1(CAG-cas9*, -EGFP)Dvs/DvsJ (Cat. No.: CEMM-07250645) | Inquiry | |
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The Rosa26CAG-LSL-Cas9-P2A-EGFP knock-in allele (RCL-Cas9-EGFP) allows Cre recombinase-dependent expression of CRISPR associated protein 9 (cas9) endonuclease and EGFP. When these mice are used in combination with guide sequences and a Cre recombinase source, they allow editing of single or multiple mouse genes both in vivo and ex vivo.
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| STOCK Gt(ROSA)26Sortm1.1(CAG-HL9-MG*V70A, -mBFP, -SNCA, -mTFP1, -SNCA*A30P, -mKO2, -SNCA*A53T)Rali Tg(Vil1-cre/ERT2)23Syr/J (Cat. No.: CEMM-07251120) | Inquiry | |
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These SNCAbow;Vil-CreERT2 mice contain α‐synuclein-Crainbow (SNCAbow) reporter and a transgene with tamoxifen-inducible Cre recombinase expression in intestinal epithelium (Vil-CreERT2), making this strain useful for studying the role of α‐synuclein expression in gut mucosal cells in early stages of Parkinson's and related neurodegenerative diseases. α‐synuclein-Crainbow (SNCAbow) has a CAG promoter followed by three pairs of orthogonal lox sites (LoxN, Lox2272, and LoxP), and the SNCAbow construct, all targeted into the Gt(ROSA)26Sor locus. SNCAbow contains four fluorescent proteins, three of which are associated with three human α-synuclein protein sequences (SNCAWT, SNCAA30P, or SNCAA53T), and functions as a Cre recombinase-inducible reporter of either a chemically inducible near‐infrared fluorogen‐activating peptide (FAPMars1) or one of the three nuclear localized fluorescent proteins. This reporter allele is available on its own as. The Vil-CreERT2 transgene is available on its own as.
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| NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-cre/Esr1*)5Amc/J (Cat. No.: CEMM-07251003) | Inquiry | |
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This compound mutant strain was developed by intercrossing NOD.Cg-Tg(CAG-cre/Esr1*)5Amc/J with NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (commonly known as NSG mice). When mice carrying the Tg(CAG-cre/Esr1*)5Amc mutation are bred with mice carrying a floxed target gene, tamoxifen-inducible Cre-mediated recombination results in deletion of the floxed sequences in widespread cells or tissues of the offspring, including developing embryos and cultured cells derived from transgenic mice. The NSG component involves two mutations on the NOD/ShiLtJ genetic background - severe combined immune deficiency (scid) and a complete null allele of the IL2 receptor common gamma chain (IL2rgnull). The scid mutation is in the DNA repair complex protein Prkdc and renders the mice B and T cell deficient. The IL2rgnull mutation prevents cytokine signaling through multiple receptors, leading to a deficiency in functional NK cells. The severe immunodeficiency allows the mice to be humanized by engraftment of human CD34+ hematopoietic stem cells (HSC), peripheral blood mononuclear cells (PBMC), patient derived xenografts (PDX), or adult stem cells and tissues. The immunodeficient NSG mice enable research in human immune function, infectious disease, diabetes, oncology, and stem cell biology.
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| B6;129-Wnt11tm1.1Sev/J (Cat. No.: CEMM-07250773) | Inquiry | |
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The Wnt11flox allele has loxP sites flanking exon 4 of the wingless-type MMTV integration site family member 11 gene. Removal of the floxed sequence creates a null allele. Wnt11flox mice may be useful in studying WNT signal transduction and WNT superfamily embryogenesis (e.g., kidney [ureteric bud branching morphogenesis], skeleton, lungs, etc.).
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| B6;129-Omptm12.1(cre/ERT2)Mom/MomJ (Cat. No.: CEMM-07250407) | Inquiry | |
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This strain expresses tamoxifen-inducible cre/ERT2 in high levels in mature olfactory sensory neurons and mature vomeronasal sensory neurons. It is valuable for the inducible expression or deletion of loxP-flanked alleles or reporters specifically in these neurons.
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| B6;129X1-Gt(ROSA)26Sortm2(ATF4)Myz/J (Cat. No.: CEMM-07250727) | Inquiry | |
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Rosa26-ATF4loxtg mutant mice carry a floxed stop/FLAG-tagged human ATF4 cassette knocked into the mouse Gt(ROSA)26Sor gene. Cre-mediate excision of the floxed stop enables site-directed expression of FLAG-tagged human ATF4 protein.
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| B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J (Cat. No.: CEMM-07250412) | Inquiry | |
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These CaMKIIalpha-cre T29-1 transgenic mice have the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) promoter driving Cre recombinase expression in the forebrain, specifically to the CA1 pyramidal cell layer in the hippocampus.
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For Research Use Only.