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B6;129-Omptm12.1(cre/ERT2)Mom/MomJ
Cat. No.: CEMM-07250407
Common Name: STOCK Omp/MomJ
This strain expresses tamoxifen-inducible cre/ERT2 in high levels in mature olfactory sensory neurons and mature vomeronasal sensory neurons. It is valuable for the inducible expression or deletion of loxP-flanked alleles or reporters specifically in these neurons.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Omptm12.1(cre/ERT2)Mom
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| Allele Name |
targeted mutation 12.1
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| Allele Attributes |
Recombinase-expressing; Inducible; Null/Knockout
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| Gene Symbol |
Omp
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| Gene Name |
olfactory marker protein
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| Chromosome |
7
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| MGI Accession ID | show more close |
| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
The endogenous coding sequence was replaced by Cre/ERT2 and the FRT flanked neomycin resistance cassette was recombined out through breeding to a transgenic mouse expressing germline FLP1 recombinase.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mice homozygous for this null allele in Omp are subfertile, although they are reported to breed. Thus, it is best to maintain this strain by transmitting the mutation from heterozygotes. As this is a knockout allele and homozygotes are OMP-deficient, it is advisable to carry out experiments with heterozygotes.
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| Breeding Strategy |
Heterozygote x +/+ sibling; +/+ sibling x Heterozygote
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For Research Use Only.
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