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B6;129-Wnt11tm1.1Sev/J

Cat. No.: CEMM-07250773

Common Name: Wnt11flox
The Wnt11flox allele has loxP sites flanking exon 4 of the wingless-type MMTV integration site family member 11 gene. Removal of the floxed sequence creates a null allele. Wnt11flox mice may be useful in studying WNT signal transduction and WNT superfamily embryogenesis (e.g., kidney [ureteric bud branching morphogenesis], skeleton, lungs, etc.).
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Wnt11tm1.1Sev
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Allele Name
targeted mutation 1.1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Wnt11
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Gene Name
wingless-type MMTV integration site family
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Chromosome
7
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MGI Accession ID
5897623
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Strain of Origin
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Molecular Note
A loxP site was inserted upstream of exon 4 and a second loxP site followed by an FRT flanked MLC-neo cassette is inserted downstream of exon 4. The selection cassette was deleted by FLP recombinase.
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HUSBANDRY
Breeding Considerations
Mice homozygous for the Wnt11flox allele are viable and fertile with no reported gross physical or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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Breeding Strategy
Homozygote x Homozygote
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For Research Use Only.
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