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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6J.129-Pex5tm1Pec/BaesJ (Cat. No.: CEMM-07250884) | Inquiry | |
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Pex52loxP (Pex5-loxP, Pex5FL) mice have loxP sites flanking exons 11-14 (the four exons encoding several tetratricopeptide repeat domains that are essential for PEX5 function). See the Detailed Description section for additional information regarding the number of loxP sites. Deletion of the floxed sequences creates a null allele. These Pex52loxP mice are useful for studying the absence of functional peroxisomes in selective organs and at different stages of life, and are a model for studying characteristics of Zellweger Spectrum Disorder (ZSD).Pex52loxP mice are available on a C57BL/6J genetic background (B6J.Pex52loxP;) and on a Swiss outbred background (SWISS.Pex52loxP;).
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| B6.Cg-Rln3tm1.1(cre/GFP)Et/J (Cat. No.: CEMM-07250967) | Inquiry | |
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Rln3-Cre mice (also called Rln3-IRES-Cre/GFP) are designed to have the endogenous relaxin 3 promoter/enhancer driving Cre/GFP fusion protein expression to nucleus incertus (NI) of the pontine tegmentum (a subset of NI GABAergic neurons) and to smaller populations of Rln3-expressing neurons found in the periaqueductal gray and adjacent to the substantia nigra. While Rln3-Cre was designed to retain endogenous Rln3 expression, this allele is hypomorphic; as such it is recommended that Rln3-Cre heterozygotes be used for Cre-lox applications. These mice may be used to generate conditional mutations in RLN3+ cells for studying physiological processes such as stress, memory and appetite regulation, as well as neuropeptide signaling processes.
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| B6;129-Pld1tm1.2Gdp/J (Cat. No.: CEMM-07250687) | Inquiry | |
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The Pld1Flox allele has loxP sites flanking exons 13-14 (including the catalytic activity-dependent first HKD motif) of the phospholipase D1 gene. Removal of the floxed sequences creates a null allele (see). These mice may be useful in studying membrane trafficking, membrane fusion, cancer and neurodegeneration.
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| B6.Cg-Pld2tm1.2Gdp/J (Cat. No.: CEMM-07250688) | Inquiry | |
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The Pld2Flox allele has loxP sites flanking exons 13-15 (including the catalytic activity-dependent first HKD motif) of the phospholipase D2 gene. Removal of the floxed sequences creates a null allele (see). These mice may be useful in studying membrane trafficking, membrane fusion, cancer, neurodegeneration and Alzheimer's disease.
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| B6.129S7(Cg)-Apptm1.1Zhe/J (Cat. No.: CEMM-07250827) | Inquiry | |
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The Appfl floxed allele has loxP sites flanking exon 3 of the amyloid precursor protein gene. Removal of the floxed sequence creates a null allele. These mice may be useful in neurobiological studies of APP, including neuronal differentiation/migration, synaptic regulation and Alzheimer's disease.
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| C57BL/6-Arid1bem2Hzhu/J (Cat. No.: CEMM-07250900) | Inquiry | |
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Arid1b Flox (Arid1bFl; floxed exon 5) mice have a CRISPR/cas9-generated, Cre-conditional knock-out allele. These mice may be useful in studying the SWI/SNF chromatin-remodeling complex, autism spectrum disorder, intellectual disability, corpus callosum agenesis and Coffin-Siris syndrome.
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| B6.Cg-Pikfyvetm1.1Ashi/J (Cat. No.: CEMM-07250726) | Inquiry | |
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The PIKfyveflox floxed allele has loxP sites flanking Pikfyve exon 6 (encoding the FYVE finger domain). Removal of the floxed sequence creates a null allele. These mice may be useful for generating tissue-specific PIKfyve-deletion for studying phosphoinositides in metabolism, diabetes, cancer, neurological disorders and other human disease.
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| STOCK Stag1tm1c(EUCOMM)Hmgu/J (Cat. No.: CEMM-07250834) | Inquiry | |
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The "conditional ready" (floxed) Stag1tm1c(EUCOMM)Hmgu allele (Stag1flox) has loxP sites flanking exon 7. Exposure to Cre recombinase creates the knock-out allele. These mice may be useful in studying the cohesin complex and STAG1 loss-of-function mutations in diseases such as neurodevelopmental disorders.
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| STOCK Syngap1tm1.1Geno/RumbJ (Cat. No.: CEMM-07250724) | Inquiry | |
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The SYNGAP1fl floxed allele has loxP sites flanking exons 6-7 of the synaptic RasGAP (SynGAP) gene. Removal of the floxed sequence disrupts expression of full-length SynGAP and results in expression of a truncated/inactive SynGAP protein. These mice may be useful in Cre-lox studies of synapse development (specifically in dendritic spine), cognitive and behavioral maturation, intellectual disability and autism spectrum disorder.
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| B6(Cg)-Asxl2tm1.1Oaw/J (Cat. No.: CEMM-07250797) | Inquiry | |
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The Asxl2fl floxed allele has loxP sites flanking exon 11 of the aadditional sex combs like 2 (Drosophila) gene. Removal of the floxed sequence creates a knock-out allele. These mice may be useful in studying hematopoiesis and transcriptional effects associated with leukemia.
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For Research Use Only.