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B6.129S7(Cg)-Apptm1.1Zhe/J
Cat. No.: CEMM-07250827
Common Name: APPfl (APP floxed exon 3)
The Appfl floxed allele has loxP sites flanking exon 3 of the amyloid precursor protein gene. Removal of the floxed sequence creates a null allele. These mice may be useful in neurobiological studies of APP, including neuronal differentiation/migration, synaptic regulation and Alzheimer's disease.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Apptm1.1Zhe
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
App
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| Gene Name |
amyloid beta (A4) precursor protein
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| Chromosome |
16
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| MGI Accession ID | show more close |
| Strain of Origin |
129S7/SvEvBrd-Hprtb-m2
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| Molecular Note |
Exon 3 was floxed. The floxed neo cassette inserted into intron 2 was removed by germ line, Cre mediated recombination.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mice homozygous for the Appfl allele are viable and fertile with no reported gross physical or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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