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B6.Cg-Pld2tm1.2Gdp/J
Cat. No.: CEMM-07250688
Common Name: Pld2Flox
The Pld2Flox allele has loxP sites flanking exons 13-15 (including the catalytic activity-dependent first HKD motif) of the phospholipase D2 gene. Removal of the floxed sequences creates a null allele (see). These mice may be useful in studying membrane trafficking, membrane fusion, cancer, neurodegeneration and Alzheimer's disease.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pld2tm1.2Gdp
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Pld2
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| Gene Name |
phospholipase D2
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6 x 129/SvJ
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| Molecular Note |
A targeting vector was designed to have a loxP site upstream of exon 13, and an FRT flanked neo cassette with 3' loxP site just downstream of exon 15 of the gene. Flp-mediated recombination removed the FRT flanked neo cassette leaving exons 13-15 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mice homozygous for Pld2Flox are viable and fertile with no reported abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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