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B6(Cg)-Asxl2tm1.1Oaw/J
Cat. No.: CEMM-07250797
Common Name: Asxl2fl
The Asxl2fl floxed allele has loxP sites flanking exon 11 of the aadditional sex combs like 2 (Drosophila) gene. Removal of the floxed sequence creates a knock-out allele. These mice may be useful in studying hematopoiesis and transcriptional effects associated with leukemia.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Asxl2tm1.1Oaw
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Asxl2
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| Gene Name |
additional sex combs like 2
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| Chromosome |
12
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6NTac
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| Molecular Note |
The targeting vector is designed to insert an FRT loxP-neomycin cassette-FRT loxP upstream of exon 11, and a loxP downstream of exon 11. Flp-mediated recombination removed the FRT flanked neo cassette leaving exon 11 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mice homozygous for the floxed allele are viable and fertile with no reported gross physical or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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