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B6J.129-Pex5tm1Pec/BaesJ
Cat. No.: CEMM-07250884
Common Name: B6J.Pex52loxP; B6J.Pex5-loxP; B6J.Pex5FL
Pex52loxP (Pex5-loxP, Pex5FL) mice have loxP sites flanking exons 11-14 (the four exons encoding several tetratricopeptide repeat domains that are essential for PEX5 function). See the Detailed Description section for additional information regarding the number of loxP sites. Deletion of the floxed sequences creates a null allele. These Pex52loxP mice are useful for studying the absence of functional peroxisomes in selective organs and at different stages of life, and are a model for studying characteristics of Zellweger Spectrum Disorder (ZSD).Pex52loxP mice are available on a C57BL/6J genetic background (B6J.Pex52loxP;) and on a Swiss outbred background (SWISS.Pex52loxP;).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pex5tm1Pec
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Pex5
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| Gene Name |
peroxisomal biogenesis factor 5
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
Four exons encompassing sequence encoding several tetratricopeptide repeat domains were flanked by an upstream floxed neo cassette and a downstream intronic loxP site. Transient transfection of ES cells with plasmids expressing Cre resulted in the excision of the floxed neo cassette, leaving single loxP sites in the introns surrounding the four exons.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mice heterozygous or homozygous for this floxed allele are viable and fertile with normal fertility and peroxisomal metabolism, and no gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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