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STOCK Syngap1tm1.1Geno/RumbJ
Cat. No.: CEMM-07250724
Common Name: SYNGAP1fl
The SYNGAP1fl floxed allele has loxP sites flanking exons 6-7 of the synaptic RasGAP (SynGAP) gene. Removal of the floxed sequence disrupts expression of full-length SynGAP and results in expression of a truncated/inactive SynGAP protein. These mice may be useful in Cre-lox studies of synapse development (specifically in dendritic spine), cognitive and behavioral maturation, intellectual disability and autism spectrum disorder.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Syngap1tm1.1Geno
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Syngap1
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| Gene Name |
synaptic Ras GTPase activating protein 1 homolog (rat)
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| Chromosome |
17
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| MGI Accession ID | show more close |
| Strain of Origin |
129S2/SvPas
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| Molecular Note |
A loxP site was inserted usptream of exon 6. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exons 6 and 7 floxed.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
Mice homozygous for the floxed allele are viable and fertile with no reported abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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