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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Tg(CAG-Bgeo, -DsRed*MST)1Nagy/J (Cat. No.: CEMM-07250034) | Inquiry | |
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These Z/RED transgenic mice express beta-galactosidase (lacZ) under the control of the chicken beta actin promoter coupled with the cytomegalovirus (CMV) immediate early enhancer. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with red fluorescent protein (DsRed*MST) expression in tissues expressing Cre recombinase. This double reporter system makes it possible to distinguish a lack of reporter expression from a lack of Cre recombinase expression while providing a means to assess Cre excision activity in live animals and cells. This strain is discontinued, please see the replacement strain:.
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| B6;FVB-Tg(Lfng-cre/ERT2)1Mmsa/J (Cat. No.: CEMM-07251026) | Inquiry | |
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Lfng-CreERT2 transgenic mice have a cre/ERT2 fusion gene under direction of the mouse LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Lfng, also known as Lunatic fringe) promoter/enhancer sequences. These mice retain normal endogenous Lfng expression and have tamoxifen-inducible Cre expressed in neural stem cells of the hippocampus.
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| STOCK Mrgprdtm1.1(cre/ERT2)Wql/J (Cat. No.: CEMM-07250851) | Inquiry | |
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MrgprdCreERT2 mice express tamoxifen-inducible Cre recombinase under the direction of the MAS-related GPR, member D promoter in non-peptidergic dorsal root ganglion and trigeminal ganglion neurons. These mice are useful for systematic sparse genetic tracing of non-peptidergic nociceptors that mediate mechanical pain and beta-alanine triggered itch.
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| STOCK Grm7Tg(SMN2)89Ahmb Smn1tm3(SMN2/Smn1)Mrph Tg(CAG-cre/Esr1*)5Amc Tg(SMN2*delta7)4299Ahmb/J (Cat. No.: CEMM-07250130) | Inquiry | |
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The severely affected "rescuable" SMA model mice, SMN2;Δ7;Cre-ER;SmnRes/Res, allow tamoxifen-inducible rescue of Type II (moderate) proximal spinal muscular atrophy.
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| B6.Cg-Gt(ROSA)26Sortm1.1(CAG-Pycard/mCitrine*, -CD2*)Dtg/J (Cat. No.: CEMM-07250824) | Inquiry | |
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The constitutively-expressed R26-CAG-ASC-citrine allele has the Gt(ROSA)26Sor locus and CAG promoter directing widespread expression of a fluorescent adaptor fusion protein (ASC-citrine) that retains the function of endogenous ASC - forming assembled inflammasome complexes (specks) upon exposure to inflammasome activator(s) both in vitro and in vivo. These R26-CAG-ASC-citrine mice are a fluorescent reporter of inflammasome complex activation.
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| B6.Cg-Gt(ROSA)26Sortm1(CAG-Pycard/mCitrine*, -CD2*)Dtg/J (Cat. No.: CEMM-07250823) | Inquiry | |
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The R26-CAG-LSL-ASC-citrine floxed allele has a CAG promoter and loxP-flanked STOP cassette upstream of the ASC-citrine fusion protein, all inserted into the Gt(ROSA)26Sor locus. Following removal of the floxed-STOP cassette, they express a fluorescent adaptor fusion protein (ASC-citrine) that retains the function of endogenous ASC - forming assembled inflammasome complexes (specks) upon exposure to inflammasome activator(s) both in vitro and in vivo. These R26-CAG-LSL-ASC-citrine mice are a Cre recombinase-dependent fluorescent reporter of inflammasome complex activation.
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| B6.Cg-Gt(ROSA)26Sortm2(CAG-rtTA3, -mKate2)Slowe/J (Cat. No.: CEMM-07250744) | Inquiry | |
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CAGs-LSL-RIK (or Rosa26-CAGs-LSL-RIK) knock-in has a CAG promoter and loxP-flanked STOP cassette upstream of the third-generation reverse tetracycline-regulated transactivator gene (rtTA3), IRES sequence and the monomeric far-red fluorescent protein mKate2, all inserted into the Gt(ROSA)26Sor locus. These mice are a Cre recombinase-dependent, Tet-On and fluorescent tool strain - following removal of the floxed-STOP cassette, they allow dox-conditional expression of TRE promoter-driven target genes in conjunction with mKate2 fluorescence.
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| B6.Cg-Gt(ROSA)26Sortm1(CAG-rtTA3)Slowe/LdowJ (Cat. No.: CEMM-07250741) | Inquiry | |
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The CAGs-LSL-rtTA3 (or Rosa26-CAGs-LSL-rtTA3) knock-in allele has a CAG promoter and loxP-flanked STOP cassette upstream of the third-generation reverse tetracycline-regulated transactivator gene (rtTA3), all inserted into the Gt(ROSA)26Sor locus. These mice are a Cre recombinase-dependent, Tet-On tool strain - following removal of the floxed-STOP cassette, they allow dox-conditional expression of TRE promoter-driven target genes.
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| B6.Cg-Serpina3ctm1.1Chao/J (Cat. No.: CEMM-07250913) | Inquiry | |
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KSfl mice have loxP sites flanking exon 3 of the kallistatin-encoding gene (Serpina3c). Cre recombinase-mediated removal of the floxed sequence creates the predicted kallistatin knock-out allele. These KSfl mice may be useful in studying oxidative stress, inflammation, apoptosis, fibrosis, angiogenesis, cancer, tumors, vascular injury and cardiovascular disease.
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| B6(Cg)-Parp1tm1c(EUCOMM)Hmgu/WlkrJ (Cat. No.: CEMM-07250924) | Inquiry | |
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Parp1loxP is a floxed allele with loxP sites flanking exon 4 of the poly (ADP-ribose) polymerase family, member 1 locus. Cre recombinase-mediated removal of the floxed sequence creates a PARP-1 knock-out allele. Parp1loxP mice may be useful in studying poly(ADP-ribosyl)ation (PARylation) in a variety of nuclear processes (including transcription, RNA processing and DNA repair).
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For Research Use Only.