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STOCK Mrgprdtm1.1(cre/ERT2)Wql/J
Cat. No.: CEMM-07250851
Common Name: MrgprdCreERT2
MrgprdCreERT2 mice express tamoxifen-inducible Cre recombinase under the direction of the MAS-related GPR, member D promoter in non-peptidergic dorsal root ganglion and trigeminal ganglion neurons. These mice are useful for systematic sparse genetic tracing of non-peptidergic nociceptors that mediate mechanical pain and beta-alanine triggered itch.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Mrgprdtm1.1(cre/ERT2)Wql
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Mrgprd
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| Gene Name |
MAS-related GPR
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| Chromosome |
7
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| Expressed Genes |
cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene
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| MGI Accession ID | show more close |
| Site of Expression |
When these mice are bred with mice containing a loxP-flanked sequence, Tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in the Cre-expressing cells of the offspring.
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| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
A targeting construct was designed to insert a CreERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) followed by a FRT flanked neomycin resistance (neo) cassette, just downstream of the start codon of the MAS-related GPR, member D (Mrgprd) gene. Breeding to B6.129S4-Gt(ROSA)26Sor/J removed the neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Mice heterozygous for MrgprdCreERT2 are viable and fertile. When maintaining a live colony, heterozygous mice may be bred to wildtype (non-carrier) mice from the colony. it has not been attempted to make this strain homozygous.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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