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B6.Cg-Serpina3ctm1.1Chao/J
Cat. No.: CEMM-07250913
Common Name: KSfl [floxed exon 3]
KSfl mice have loxP sites flanking exon 3 of the kallistatin-encoding gene (Serpina3c). Cre recombinase-mediated removal of the floxed sequence creates the predicted kallistatin knock-out allele. These KSfl mice may be useful in studying oxidative stress, inflammation, apoptosis, fibrosis, angiogenesis, cancer, tumors, vascular injury and cardiovascular disease.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Serpina3ctm1.1Chao
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Serpina3c
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| Gene Name |
serine (or cysteine) peptidase inhibitor
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| Chromosome |
12
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| MGI Accession ID | show more close |
| Strain of Origin |
Not Specified
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| Molecular Note |
The targeting vector is designed to have a loxP site upstream of exon 3, and an FRT flanked neo cassette followed by a loxP site just downstream of exon 3 of the gene. Flp-mediated recombination removed the FRT flanked neo cassette leaving exon 3 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mice heterozygous or homozygous for this floxed allele are viable and fertile with normal breeding, and no reported gross physical or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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