Online Inquiry
Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129S4-Ndufs4tm1Rpa/J (Cat. No.: CEMM-07250626) | Inquiry | |
|
Exon 2 of the mouse Ndufs4 gene is flanked by loxP sites in this conditional mutant strain. Cre-mediated excision of the floxed region results in a knockout allele, useful in studies of mitochondrial disorders.
show more
close
|
||
| B6.Cg-Ccn3tm1.1Jt/J (Cat. No.: CEMM-07250685) | Inquiry | |
|
Exons 3 and 4 of the mouse Nov gene are flanked by loxP sites. Brain-specific cre-mediated excision of the floxed region in the brain results in a mild anxiolytic effect.
show more
close
|
||
| B6.129-Grm5tm1.1Jixu/J (Cat. No.: CEMM-07250686) | Inquiry | |
|
Exon 7 of the mouse Grm5 gene is flanked by loxP sites. Cre-mediated excision of the exon results in a knockout allele.
show more
close
|
||
| STOCK Get1tm1.1Dpc/J (Cat. No.: CEMM-07250697) | Inquiry | |
|
Exons 2-4 of the mouse Get1 (formerly Wrb) gene are flanked by loxP sites in this targeted mutant strain. Cre-mediated excision of the floxed region is believed to result in a knockout allele. The human homolog maps to Chromosome 21q22.3 in a region associated with Down Syndrome. Mutations in the zebrafish homolog have been shown to result in blindness and deafness.
show more
close
|
||
| B6.129S(Cg)-Ank3tm3.1Bnt/J (Cat. No.: CEMM-07250759) | Inquiry | |
|
Exon 37, the "giant exon" of the Ankyrin-G (Ank3) gene, is flanked by loxP sites in this conditional mutant strain. Cre-mediated excision of the floxed region blocks the expression of a 480-kDa isoform.
show more
close
|
||
| B6(Cg)-Nalcntm1c(KOMP)Wtsi/DrenJ (Cat. No.: CEMM-07250822) | Inquiry | |
|
Exons 5 and 6 of the mouse Nalcn gene are flanked by loxP sites. Cre-mediated excision of the floxed region results in a knock-out allele.
show more
close
|
||
| B6.129-Nrxn1tm3Sud/J (Cat. No.: CEMM-07250458) | Inquiry | |
|
The last coding exon (exon 24) of the Nrxn1 (neurexin 1) gene is flanked by loxP sites in this conditional mutant allele. Cre excision of the floxed segment enables the production of truncated protein. A 2xHA (hemagglutinin) tag outside of the floxed region provides a useful marker.
show more
close
|
||
| B6.129(Cg)-Phox2btm1Rth/J (Cat. No.: CEMM-07250564) | Inquiry | |
|
In this targeted mutant strain, exon 3 of the mouse Phox2b gene is flanked by loxP sites and exon 3 of the human PHOX2B gene, modified with an 8 bp deletion and EGFP marker, has been placed downstream. Cre-mediated excision of the floxed exon knocks out expression of the mouse form of protein, but allows the mutant human form and EGFP to be expressed.
show more
close
|
||
| STOCK Gt(ROSA)26Sortm1Phep/J (Cat. No.: CEMM-07250599) | Inquiry | |
|
These Rosa26SNAPCaaX reporter mice conditionally express membrane-localized SNAP-tag from the Gt(ROSA)26Sor promoter upon cre-mediated excision of a floxed stop cassette. Cells expressing the SNAP-tag can be selectively labeled through treatment with benzylguanine (BG)-linked compounds, including synthetic fluorophores.
show more
close
|
||
| STOCK Fzd9tm1.1Nat/J (Cat. No.: CEMM-07250661) | Inquiry | |
|
Fzd9 coding region sequences are flanked by loxP sites in this Fzd9-CKO-AP allele. Cre-mediated recombination of the floxed region creates a knockout of the gene and enables expression of the alkaline phosphatase coding region under the control of the Fzd9 promoter.
show more
close
|
||
For Research Use Only.