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B6.129S4-Ndufs4tm1Rpa/J
Cat. No.: CEMM-07250626
Exon 2 of the mouse Ndufs4 gene is flanked by loxP sites in this conditional mutant strain. Cre-mediated excision of the floxed region results in a knockout allele, useful in studies of mitochondrial disorders.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ndufs4tm1Rpa
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ndufs4
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| Gene Name |
NADH:ubiquinone oxidoreductase core subunit S4
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| Chromosome |
13
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJaeSor
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| Molecular Note |
An FRT flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 and an additional loxP site was inserted upstream of exon 2. Germ line, flp mediated recombination was used to remove the neo cassette. Exon 2 contains the mitochondrial targeting sequence.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Homozygous and heterozygous floxed mice are viable and fertile.
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For Research Use Only.
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