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STOCK Fzd9tm1.1Nat/J
Cat. No.: CEMM-07250661
Common Name: Fzd9-CKO-AP
Fzd9 coding region sequences are flanked by loxP sites in this Fzd9-CKO-AP allele. Cre-mediated recombination of the floxed region creates a knockout of the gene and enables expression of the alkaline phosphatase coding region under the control of the Fzd9 promoter.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Fzd9tm1.1Nat
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; No functional change
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| Gene Symbol |
Fzd9
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| Gene Name |
frizzled class receptor 9
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| Chromosome |
5
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| Expressed Genes |
ALPP, alkaline phosphatase, placental, human
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
LoxP sites were inserted (1) within the first coding exon 5' of the initiator methionine codon, and (2) 3' of an SV40 polyadenylation signal that was inserted immediately 3' of the 3' UTR. The following DNA segments were added immediately downstream of the 3' loxP site: (1) the coding region for human placental alkaline phosphatase (AP), and (2) a phosphoglycerate kinase (PGK)-Neo cassette flanked by FRT sites (FNF). Flp-mediated recombination removed the FRT flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
Homozygous and heterozygous mice are viable and fertile.
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| Breeding Strategy |
C57BL/6J x Heterozygote; Heterozygote x C57BL/6J
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For Research Use Only.
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