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STOCK Get1tm1.1Dpc/J

Cat. No.: CEMM-07250697

Common Name: Wrb conditional knock-out
Exons 2-4 of the mouse Get1 (formerly Wrb) gene are flanked by loxP sites in this targeted mutant strain. Cre-mediated excision of the floxed region is believed to result in a knockout allele. The human homolog maps to Chromosome 21q22.3 in a region associated with Down Syndrome. Mutations in the zebrafish homolog have been shown to result in blindness and deafness.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Get1tm1.1Dpc
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Allele Name
targeted mutation 1.1
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Allele Attributes
Null/Knockout
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Gene Symbol
Get1
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Gene Name
guided entry of tail-anchored proteins factor 1
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Chromosome
16
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MGI Accession ID
3814435
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Strain of Origin
(C57BL/6NTac x 129S6/SvEvTac)F1
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Molecular Note
A loxP site was inserted 5' to exon 2, and a loxP- and FRT flanked neomycin cassette was placed 3' to exon 4. The FRT flanked neomcycin cassette was deleted by crossing the mice with a widely-expressed Flp strain. To Create this allele (delta P), the floxed exons were also excised by crossing to a widely expressing Cre strain, leaving a single loxP site.
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HUSBANDRY
Suggested Controls
Wild-type from the colony
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Breeding Considerations
Homozygous and heterozygous floxed mice are viable and fertile.
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Breeding Strategy
Heterozygote x Heterozygote
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For Research Use Only.
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