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B6.129S(Cg)-Ank3tm3.1Bnt/J
Cat. No.: CEMM-07250759
Common Name: Ank3 floxed exon 37 (480-kDa isoform)
Exon 37, the "giant exon" of the Ankyrin-G (Ank3) gene, is flanked by loxP sites in this conditional mutant strain. Cre-mediated excision of the floxed region blocks the expression of a 480-kDa isoform.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ank3tm3.1Bnt
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| Allele Name |
targeted mutation 3.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ank3
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| Gene Name |
ankyrin 3
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
A loxP site was placed in intron 36 and an FRT loxP-neomycin-FRT loxP cassette was introduced to intron 37 via homologous recombination. Flp-mediated recombination removed the FRT flanked neo cassette leaving exon 37 floxed. The version of this allele that contains the neomycin selection cassette, Ank3tm3Bnt, has been analyzed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Homozygous and heterozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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