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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| C57BL/6N-Sned1tm1a(KOMP)Wtsi/HynMmjax (Cat. No.: CEMM-07250908) | Inquiry | |
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Sned1LacZ-Neo mice carry a knock-out first, conditional-ready, lacZ-tagged allele of the mouse Sned1 gene. Most homozygotes die within 2 days of being born. The rare knock-out survivors present severe craniofacial defects (shorter snouts, asymmetrical nasal cavities) and growth retardation.
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| B6.Cg-Gcgtm1.1(cre/GFP)Rpa/J (Cat. No.: CEMM-07250809) | Inquiry | |
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These targeted mutant mice express cre recombinase from the mouse Gcg (glucagon) promoter in Gcg-expressing cells of the nucleus tractus solitarius (NTS).
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| B6J.Cg-Gt(ROSA)26Sortm95.1(CAG-GCaMP6f)Hze/MwarJ (Cat. No.: CEMM-07250704) | Inquiry | |
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Ai95(RCL-GCaMP6f)-D (also called Ai95D) mice are a Cre-dependent, fluorescent, calcium-indicator tool strain. Ai95D has a floxed-STOP cassette preventing transcription of the GCaMP6 fast variant calcium indicator (GCaMP6f; a detector of single neuronal action potentials with fast response kinetics). After Cre exposure, bright EGFP fluorescence is observed following calcium binding (such as neuronal activation).
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| B6;129S6-Adgrl2tm1Sud/J (Cat. No.: CEMM-07250495) | Inquiry | |
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This mouse line ("CL2") carries a set of linked heterologous Frt sites and a pair of loxP sites which can be manipulated to conditionally knockout the endogenous Lphn2 (latrophilin 2) gene through cre-mediated excision and/or express a specific Frt-flanked Lphn2 alternative transcript (NM_001081298.1) knock-in fused to mVenus green fluorescent protein.
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| B6.Cg-Hdac2tm1.1Rdp/J (Cat. No.: CEMM-07250476) | Inquiry | |
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These mice carry a floxed allele of the Hdac2 (histone deacetylase 2) gene. Exons 5 and 6, encoding the HDAC-catalytic core of the protein, are flanked by loxP sites. Cre-mediated excision of the floxed segment results in a null genotype, lacking protein expression. HDAC2 deficiency results in increased synapse number and memory facilitation.
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| B6.129(SJL)-Grip1tm1Rlh/J (Cat. No.: CEMM-07250538) | Inquiry | |
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The first PDZ domain of Grip1 is flanked by loxP sites in this conditional knockout strain. This enables the development of Cre-mediated knockouts useful in studies of synaptic plasticity.
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| STOCK Drd1tm2.1Stl/J (Cat. No.: CEMM-07250573) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking the single exon of the Ddr1a gene. This strain may be useful for generating conditional mutations for applications related to behavioral responses.
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| STOCK Rettm1.2Ddg/J (Cat. No.: CEMM-07250674) | Inquiry | |
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Exons 14 and 15 of the mouse Ret gene are flanked by loxP sites in this conditional mutant strain. Cre-mediated excision of the floxed region results in a knockout allele. A V805A mutation in exon 15 is functionally silent, but sensitizes the protein to chemical inhibition of its kinase activity.
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| STOCK Cbfbtm2.1Ddg/J (Cat. No.: CEMM-07250675) | Inquiry | |
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Exons 1 and 2 of the mouse Cbfb gene are flanked by loxP sites in this conditional mutant strain. Cre-mediated excision of the floxed region in the Cbfbf mice results in a knockout allele.
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| STOCK Bmi1tm1.1Sjm/J (Cat. No.: CEMM-07250708) | Inquiry | |
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Exons 1 and 2 of the mouse Bmi1 gene are flanked by loxP sites in this conditional knockout allele. This strain has been useful in studies of stem cell and neurosphere-initiating cells in the adult mouse forebrain.
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For Research Use Only.