Online Inquiry
STOCK Bmi1tm1.1Sjm/J
Cat. No.: CEMM-07250708
Common Name: Bmi1fl
Exons 1 and 2 of the mouse Bmi1 gene are flanked by loxP sites in this conditional knockout allele. This strain has been useful in studies of stem cell and neurosphere-initiating cells in the adult mouse forebrain.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Bmi1tm1.1Sjm
show more
close
|
| Allele Name |
targeted mutation 1.1
show more
close
|
| Allele Attributes |
Conditional ready (e.g. floxed)
show more
close
|
| Gene Symbol |
Bmi1
show more
close
|
| Gene Name |
Bmi1 polycomb ring finger oncogene
show more
close
|
| Chromosome |
2
show more
close
|
| MGI Accession ID | show more close |
| Site of Expression |
When bred to mice carrying Cre recombinase, compound mutant mice exhibit loss of BMI1 protein in the cortex and subventricular zone of the brain.
show more
close
|
| Strain of Origin |
129S6/SvEvTac
show more
close
|
| Molecular Note |
A loxP site and an FRT flanked neo cassette were inserted upstream the first coding exon and a loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette.
show more
close
|
| HUSBANDRY | |
|---|---|
| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
show more
close
|
| Breeding Strategy |
Homozygote x Homozygote
show more
close
|
For Research Use Only.
Related Products