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STOCK Rettm1.2Ddg/J
Cat. No.: CEMM-07250674
Common Name: Retf
Exons 14 and 15 of the mouse Ret gene are flanked by loxP sites in this conditional mutant strain. Cre-mediated excision of the floxed region results in a knockout allele. A V805A mutation in exon 15 is functionally silent, but sensitizes the protein to chemical inhibition of its kinase activity.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rettm1.2Ddg
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ret
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| Gene Name |
ret proto-oncogene
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
Exons 14 and 15 and an FRT flanked neo cassette are flanked by loxP sites. A missense mutation in exon 15 changes valine 805 to alanine. This mutation is silent but sensitizes the protein to chemical inhibition of its kinase activity. Flp-mediated recombination removed the FRT flanked neo cassette leaving exons 14 and 15 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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For Research Use Only.
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