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B6;129S6-Adgrl2tm1Sud/J
Cat. No.: CEMM-07250495
This mouse line ("CL2") carries a set of linked heterologous Frt sites and a pair of loxP sites which can be manipulated to conditionally knockout the endogenous Lphn2 (latrophilin 2) gene through cre-mediated excision and/or express a specific Frt-flanked Lphn2 alternative transcript (NM_001081298.1) knock-in fused to mVenus green fluorescent protein.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Adgrl2tm1Sud
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter
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| Gene Symbol |
Adgrl2
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| Gene Name |
adhesion G protein-coupled receptor L2
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| Chromosome |
3
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| Expressed Genes |
Adgrl2, adhesion G protein-coupled receptor L2, mouse, laboratory; GFP, Green Fluorescent Protein
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| MGI Accession ID | show more close |
| Site of Expression |
Dendritic spines in the stratum lacunosum-moleculare in CA1-region hippocampal neurons.
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| Strain of Origin |
129S6/SvEvTac x C57BL/6J
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| Molecular Note |
A targeting vector was designed to introduce a loxP site upstream of the first coding exon (exon 2). A segment carrying an F1 FRT site, FRT site, 1 kb of the mouse engrailed splice acceptor, 5 kb of Adgrl2 cDNA fused to mVenus green fluorescent protein, a polyA signal, FRT site, PGK-neomycin resistance cassette, tandem FRT and F1 FRT sites, and a loxP site were placed in intron 2.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
Heterozygous and homozygous "CL2" mice are viable and fertile. Knockouts of the endogenous Lphn2 gene are not viable.
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For Research Use Only.
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