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B6.Cg-Hdac2tm1.1Rdp/J
Cat. No.: CEMM-07250476
These mice carry a floxed allele of the Hdac2 (histone deacetylase 2) gene. Exons 5 and 6, encoding the HDAC-catalytic core of the protein, are flanked by loxP sites. Cre-mediated excision of the floxed segment results in a null genotype, lacking protein expression. HDAC2 deficiency results in increased synapse number and memory facilitation.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Hdac2tm1.1Rdp
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Hdac2
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| Gene Name |
histone deacetylase 2
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
LoxP sites were inserted upstream of exon 5 and downstream of exon 6. Protein expression was unaffected as determined by immunoblot analysis of embryonic fibroblasts. Cre-mediated recombination removed the drug selection cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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