Online Inquiry
Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J (Cat. No.: CEMM-07250073) | Inquiry | |
|
These Brainbow transgenic mice allow labeling of individual neuronal types with distinguishable color variations in cre recombined cells, and may be useful in analyses of neuronal circuitry.
show more
close
|
||
| B6.Cg-Igs7tm161.1(tetO-EGFP, CAG-tTA2)Hze/J (Cat. No.: CEMM-07250874) | Inquiry | |
|
Ai161(TIT2L-GFP-ICR-tTA2)-D (also called Ai161D) mice are a Dre and Cre-dependent, Tet-controllable fluorescent reporter line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Dre recombinase removes the rox-flanked STOP cassette and results in tTA2 expression. Subsequent exposure to Cre recombinase removes the loxP-flanked STOP cassette - allowing the tTA2 to induce EGFP expression. The EGFP expression may then be diminished by doxycycline. Ai161D mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of the two gene promoters driving the expression of each recombinase.
show more
close
|
||
| B6.FVB-Tg(Pomc-cre)1Lowl/J (Cat. No.: CEMM-07250200) | Inquiry | |
|
The mouse pro-opiomelanocortin-alpha (Pomc) promoter drives expression of cre primarily in the granule cells of the dentate gyrus subregion of the hippocampus.
show more
close
|
||
| C57BL/6J-Gt(ROSA)26Sorem1Naik/J (Cat. No.: CEMM-07251125) | Inquiry | |
|
LoxCode knock-in mice have the LoxCode cassette inserted into the endogenous Gt(ROSA)26Sor locus. The LoxCode cassette is composed of 14 loxP sites in alternating orientation flanking 13 small (8-14nts) code elements. Upon Cre exposure, random recombination between the loxP sites lead to inversions and excisions, resulting in DNA sequence reshuffling with a theoretical DNA diversity of over 30 billion barcodes. This is an inducible, cellular barcoding technology based on the Cre-loxP system that allows for sensitive, high diversity lineage tracing at the cellular, spatial, and tissue level.
show more
close
|
||
| FVB/N-Tg(Thy1-cre)1Vln/J (Cat. No.: CEMM-07250041) | Inquiry | |
|
Cre expression is driven in neurons of the postnatal cortex and hippocampus of hemizygous mice. These mice may be useful in studies of the nervous system, including Alzheimer's disease.
show more
close
|
||
| STOCK Gt(ROSA)26Sortm1(Luc)Kael Tg(UBC-CCR5, -CD4)19Mnz/J (Cat. No.: CEMM-07250501) | Inquiry | |
|
These transgenic mice express human CD4 and CCR5 under the regulatory control of the human ubiquitin C promoter in combination with a widely-expressed luciferase reporter regulated by the Gt(ROSA)26Sor promoter. The mice enable the rapid measurement of HIV-1 transmission by peritoneal and genitomucosal HIV-1 pseudovirus entry in vivo. The system represents a model for the pre-clinical evaluation of prophylactic or vaccine candidates.
show more
close
|
||
| STOCK Gt(ROSA)26Sortm1(CAG-EYFP*, -mEYFP*, -tdTomato*, -mTFP1*)Ben/J (Cat. No.: CEMM-07250854) | Inquiry | |
|
iMb2-Control-Mosaic mice allow three possible Cre recombination outcomes in any single cell. Each outcome results in expression of a membrane-bound fluorescent protein, and each is mutually exclusive and permanent. These mice are also designed to permit further introduction of genes of interest for inducible, fluorescent and functional genetic mosaic analysis (ifgMosaic). Mice are available with the similarly-designed iChr2-Control-Mosaic allele harboring chromatin/nuclear-targeted fluorescent proteins. In addition, the iMb2-Control-Mosaic::iChr2-Control-Mosaic compound heterozygous mice harbor both alleles.
show more
close
|
||
| STOCK Gt(ROSA)26Sortm2(CAG-EYFP*, -mCherry*, -EGFP*, -mCerulean*)Ben/J (Cat. No.: CEMM-07250855) | Inquiry | |
|
iChr2-Control-Mosaic mice allow three possible Cre recombination outcomes in any single cell. Each outcome results in expression of a chromatin/nuclear-targeted fluorescent protein, and each is mutually exclusive and permanent. These mice are also designed to permit further introduction of genes of interest for inducible, fluorescent and functional genetic mosaic analysis (ifgMosaic). Mice are available with the similarly-designed iMb2-Control-Mosaic allele harboring membrane-bound fluorescent proteins. In addition, the iMb2-Control-Mosaic::iChr2-Control-Mosaic compound heterozygous mice harbor both alleles.
show more
close
|
||
| B6J.129S6(FVB)-Slc32a1tm2(cre)Lowl/MwarJ (Cat. No.: CEMM-07250701) | Inquiry | |
|
Vgat-ires-Cre knock-in mice have Cre recombinase expression directed to inhibitory GABAergic neuron cell bodies, without disrupting endogenous vesicular inhibitory amino acid transporter expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to GABAergic neuronal function.
show more
close
|
||
| C57BL/6-Gt(ROSA)26Sortm1(CAG-hVOS1.5)Mbja/J (Cat. No.: CEMM-07250846) | Inquiry | |
|
Ai35-hVOS1.5 mice have a loxP-flanked STOP cassette that prevents transcription of hVOS1.5 - an optimized hybrid voltage sensor consisting of cerulean fluorescent protein with a C-terminal truncated h-ras membrane-anchoring motif. This Ai35-hVOS1.5 Cre reporter mouse line allows bright fluorescent imaging of rapid voltage changes with high temporal resolution in the cell populations defined by Cre recombinase expression.
show more
close
|
||
For Research Use Only.