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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129(Cg)-Cacna2d1tm1.1Gfng/J (Cat. No.: CEMM-07250820) | Inquiry | |
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These Cavα2δ1 floxed mutant mice possess loxP sites flanking exon 6 of the Cacna2d1 gene. This strain may be useful for generating conditional mutations in applications related to nociception and peripheral nerve injury.
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| B6.Cg-Traf6tm2.1Ywc/J (Cat. No.: CEMM-07250829) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 7 of the Traf6 gene and a STOP cassette, with a downstream IRES-YFP. Cre recombinase-mediated excision of exon 7 and the STOP cassette generates a null allele and allows expression of the YFP from the endogenous Traf6 locus. This strain may be useful for generating conditional mutations in applications related to signal transduction, autophagy regulation, TRAF pathway and toll-like receptor (TLR) pathway.
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| B6(Cg)-Rhoqtm1.1Pkm/J (Cat. No.: CEMM-07250835) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 2 of the Rhoq gene. This strain may be useful for generating conditional mutations in applications related to actin cytoskeleton reorganization, the immune synapse, and the insulin pathway.
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| B6;129-Mdm4tm2Glo/J (Cat. No.: CEMM-07250839) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 2 of the Mdm4 gene. This strain may be useful for generating conditional mutations in applications related to the role of the MDM2/MDMX-p53 pathway in embryogenesis, development and tumorigenesis.
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| STOCK Arl13btm1.1Tc/J (Cat. No.: CEMM-07250843) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 2 of the Arl13b gene. This strain may be useful for generating conditional mutations in applications related to ciliogenesis and neurodevelopmental disorders.
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| STOCK Ngfrtm1.1Vk/BnapJ (Cat. No.: CEMM-07250849) | Inquiry | |
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These p75NTR-FX, mutant mice possess loxP sites flanking exons 4 through 6 of the Ngfr gene. This strain may be useful for generating conditional mutations in applications related to neuronal electrophysiology, neuronal progenitor cell cycle and neural cell survival.
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| STOCK Vangl1tm1Jdax/J (Cat. No.: CEMM-07250862) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 4 of the Vangl1 gene. This strain may be useful for generating conditional mutations in applications related to studies of the planar cell polarity (PCP)/non-canonical Wnt signaling pathway.
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| B6.129(Cg)-Ank2tm1.1Pmoh/MnrJ (Cat. No.: CEMM-07250866) | Inquiry | |
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Ankyrin-B floxed mice possess loxP sites flanking exon 24 of the Ank2 gene. This strain may be useful for generating conditional mutations in applications related to the study of neuronal paranodal junctions, and localization and membrane stabilization of integral membrane proteins, such as ion transporters.
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| B6.FVB-Agtr1aem1(cre)Zak/J (Cat. No.: CEMM-07250871) | Inquiry | |
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Agtr1a-2A-Cre knock-in mice are designed to have Cre recombinase expression directed to Agtr1a-expressing cells. Cre activity recapitulates that of the endogenous Agtr1a gene in the brain. These mice may be used to generate conditional mutations for studying neural circuits underlying thirst, vasopressin secretion, and fluid homeostasis.
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| STOCK Mdm2tm2.1Glo/J (Cat. No.: CEMM-07250882) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 5 and 6 of the Mdm2 gene. This strain may be useful for generating conditional mutations in applications related to the role of the MDM2/MDMX-p53 pathway in embryogenesis, development and tumorigenesis.
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For Research Use Only.