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B6.129(Cg)-Ank2tm1.1Pmoh/MnrJ
Cat. No.: CEMM-07250866
Common Name: Ankyrin-B cKO; Ank2 flox
Ankyrin-B floxed mice possess loxP sites flanking exon 24 of the Ank2 gene. This strain may be useful for generating conditional mutations in applications related to the study of neuronal paranodal junctions, and localization and membrane stabilization of integral membrane proteins, such as ion transporters.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ank2tm1.1Pmoh
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Ank2
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| Gene Name |
ankyrin 2
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| Chromosome |
3
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| MGI Accession ID | show more close |
| Strain of Origin |
129/Sv
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| Molecular Note |
Exon 24 was floxed via homologous recombination, the construct also includes an FRT flanked neomycin cassette. Flp-mediated recombination removed the FRT flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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