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B6.Cg-Traf6tm2.1Ywc/J
Cat. No.: CEMM-07250829
Common Name: Traf6floxed
These floxed mutant mice possess loxP sites flanking exon 7 of the Traf6 gene and a STOP cassette, with a downstream IRES-YFP. Cre recombinase-mediated excision of exon 7 and the STOP cassette generates a null allele and allows expression of the YFP from the endogenous Traf6 locus. This strain may be useful for generating conditional mutations in applications related to signal transduction, autophagy regulation, TRAF pathway and toll-like receptor (TLR) pathway.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Traf6tm2.1Ywc
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Traf6
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| Gene Name |
TNF receptor-associated factor 6
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
Not Specified
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| Molecular Note |
A floxed neomycin selection cassette was placed upstream of exon 7 and a STOP cassette followed by a loxP site and an YFP reporter were placed downstream of exon 7. Cre-mediated recombination removed the floxed neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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