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STOCK Mdm2tm2.1Glo/J
Cat. No.: CEMM-07250882
Common Name: floxed mdm2 (FM)
These floxed mutant mice possess loxP sites flanking exons 5 and 6 of the Mdm2 gene. This strain may be useful for generating conditional mutations in applications related to the role of the MDM2/MDMX-p53 pathway in embryogenesis, development and tumorigenesis.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Mdm2tm2.1Glo
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Mdm2
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| Gene Name |
transformed mouse 3T3 cell double minute 2
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
129S7/SvEvBrd-Hprt+
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| Molecular Note |
The floxed neo cassette of Mdm2tm2Glo was excised from intron 6 via germline expression of Cre recombinase. Exons 5 and 6, encoding most of the Trp53-binding domain (residues 53 through 113), were left flanked by single loxP sites in introns 4 and 6.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as homozygotes.
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| Breeding Strategy |
Homozygote x Homozygote
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| Coat Color |
The coat color is black.
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For Research Use Only.
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