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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129-Gt(ROSA)26Sortm1(CAG-KDM1A/EGFP)Rsd/J (Cat. No.: CEMM-07250897) | Inquiry | |
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Cre-mediated excision of a floxed Stop in these LSD1 WT mice enables expression of FLAG-tagged human KDM1A (LSD1) cDNA encoding LSD1c isoforms of the gene, as well as an EGFP fluorescent reporter. These mice have been used for chromatin immunoprecipitation (ChIP) analysis.
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| B6N.129-Gt(ROSA)26Sortm2(CAG-KDM1A/EGFP)Rsd/J (Cat. No.: CEMM-07250898) | Inquiry | |
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Cre-mediated excision of a floxed Stop in these LSD1 VN mice enables expression of FLAG-tagged human KDM1A (LSD1) cDNA encoding LSD1n isoforms of the gene, as well as an EGFP fluorescent reporter. These mice have been used for chromatin immunoprecipitation (ChIP) analysis.
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| B6.Cg-Gt(ROSA)26Sortm1(CAG-mNeonGreen/mRuby2)Mnz/J (Cat. No.: CEMM-07250901) | Inquiry | |
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Cre-mediated excision of a loxP-flanked stop cassette enables tissue-specific expression of the INDIA apoptosis reporter in these Rosa26LSL-INDIA mice. When aCasp3 (Casp3, caspase 3; a marker for apoptosis) cleaves a linker, the mNeonGreen and mRuby2 components of INDIA are separated, resulting in FRET loss and increased emission from mNeonGreen.
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| STOCK Gt(ROSA)26Sortm1(CAG-COX4I1/APX1*)Ddg/J (Cat. No.: CEMM-07250928) | Inquiry | |
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ROSA26DR-Matrix-dAPEX2 mice conditionally express mitochondrial matrix-targeted dimeric APEX2 (Matrix-dAPEX2, an enhanced soybean ascorbate peroxidase) in a cre and Flp dual recombinase-dependent manner. This multiplexed peroxidase-mediated electron microscopy (EM) labeling system facilitates the analysis of connectivity in the mammalian nervous system.
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| STOCK Gt(ROSA)26Sortm1.1(CAG-COX4I1/APX1*)Ddg/J (Cat. No.: CEMM-07250929) | Inquiry | |
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ROSA26LSL-Matrix-dAPEX2 mice conditionally express mitochondrial matrix-targeted dimeric APEX2 (Matrix-dAPEX2, an enhanced soybean ascorbate peroxidase) in a cre recombinase-dependent manner. This peroxidase-mediated electron microscopy (EM) labeling system facilitates the analysis of connectivity in the mammalian nervous system.
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| STOCK Gt(ROSA)26Sortm2(CAG-APX1*)Ddg/J (Cat. No.: CEMM-07250930) | Inquiry | |
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ROSA26DR-ER-dAPEX2 mice conditionally express endoplasmic reticulum-targeted dimeric APEX2 (ER-dAPEX2, an enhanced soybean ascorbate peroxidase) in a cre and Flp dual recombinase-dependent manner. This multiplexed peroxidase-mediated electron microscopy (EM) labeling system facilitates the analysis of connectivity in the mammalian nervous system.
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| B6.FVB-Nxph4em1(cre)Zak/J (Cat. No.: CEMM-07250948) | Inquiry | |
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Nxph4-2a-Cre knock-in mice express Cre recombinase from the mouse Nxph4 (neurexophilin 4) promoter. Cre activity recapitulates that of the endogenous Nxph4 gene in the brain. These mice may be useful in studies of study thirst, thermoregulation, and other processes regulated by neurons expressing Nxph4.
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| STOCK Bhlhe40tm1Rhli/NgcTesDamJ (Cat. No.: CEMM-07250986) | Inquiry | |
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The Bhlhe40 conditional knockout (cko) strain may be useful in applications related to circadian rhythms, cellular growth, immune responses, and transcriptional regulation.
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| STOCK Grin1tm1Zwz/J (Cat. No.: CEMM-07250995) | Inquiry | |
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Grin1floxedEx5 mice carry loxP sites flanking Grin1 (glutamate receptor, ionotropic, NMDA1 (zeta 1)) exon 5. Deletion of exon 5 disrupts the maturation of excitatory synapses in the thalamus and cortex, and increases seizure susceptibility. This allele does not enable the production of complete gene knock-outs.
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| STOCK Gt(ROSA)26Sortm3.1(CAG-HRP)Ddg/J (Cat. No.: CEMM-07250996) | Inquiry | |
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ROSA26LSL-ER-HRP mice conditionally express endoplasmic reticulum (ER)-targeted horse radish peroxidase (HRP) in a Cre recombinase-dependent manner. Cre recombinase-mediated excision of a loxP-flanked Stop cassette enables directed expression of horse radish peroxidase fused to an endoplasmic reticulum retention signal, useful in multiplexed electron microscopy labeling. The donating laboratory describes this strain as an ER-ERP strain: horseradish peroxidase fused to immunoglobulin kappa light chain leader sequence and KDEL endoplasmic reticulum retention signal.
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For Research Use Only.