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STOCK Grin1tm1Zwz/J
Cat. No.: CEMM-07250995
Common Name: Grin1floxedEx5
Grin1floxedEx5 mice carry loxP sites flanking Grin1 (glutamate receptor, ionotropic, NMDA1 (zeta 1)) exon 5. Deletion of exon 5 disrupts the maturation of excitatory synapses in the thalamus and cortex, and increases seizure susceptibility. This allele does not enable the production of complete gene knock-outs.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Grin1tm1Zwz
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Grin1
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| Gene Name |
glutamate receptor
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6J
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| Molecular Note |
A loxP site was introduced to intron 4 and an FRT PGK-Neo-FRT loxP selection cassette was placed in intron 5. Flp-mediated recombination removed the FRT flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygotes and homozygotes are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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