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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S-Hoxb1tm1(cre)Og/J (Cat. No.: CEMM-07250221) | Inquiry | |
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These Hoxb1 Cre recombinase knock-in mice may be useful for generating mutations to study fate mapping of cell lineages derived from rhombomere 4 (r4) of the hindbrain.
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| FVB-Tg(CAG-cat, -Twist1)1Dbsp/J (Cat. No.: CEMM-07250404) | Inquiry | |
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This CAG-CAT-Twist1 transgenic line expresses mouse Twist1, twist homolog 1 (Drosophila), gene in a Cre recombinase inducible fashion, and has applications in studies of craniofacial development, cartilage formation, endochondral ossification and heart valve development.
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| B6;129P-Tg(Neurog1-cre/ERT2)1Good/J (Cat. No.: CEMM-07250114) | Inquiry | |
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When these Ngn1-CreERT2 transgenic mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Neurog1 expressing cells such as neurons in the cortex, hippocampus, thalamus, hypothalamus and the cochlear-vestibular ganglion. This mutant mouse strain may be useful for studying neuron development and lineage mapping of Neurog1 expressing cells.
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| B6(C3)-Trem2tm1c(EUCOMM)Wtsi/AdiujJ (Cat. No.: CEMM-07250765) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 2 and 3 of the Trem2 gene. This strain may be useful for generating conditional mutations in applications related to Alzheimer's Disease.
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| B6.129S2(Cg)-Bdnftm1Krj/J (Cat. No.: CEMM-07250433) | Inquiry | |
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These mice possess loxP sites flanking exon 5 of the brain derived neurotrophic factor (Bdnf) gene, as well as a Cre recombinase-mediated beta-galactosidase reporter and have applications in studies of neuronal survival and differentiation, synaptic function and behavior.
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| B6(Cg)-Chrna7tm1.1Ehs/YakelJ (Cat. No.: CEMM-07250627) | Inquiry | |
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α7nAChRflox mice have loxP sites flanking exon 4 of the Chrna7 gene. This strain may be useful for generating conditional mutations in studies of possible therapeutic targets for cognitive defects and applications related to the cholinergic anti-inflammatory pathway. This floxed allele acts as a hypomorph - see Detailed Description for more information.
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| C57BL/6-Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple/J (Cat. No.: CEMM-07250560) | Inquiry | |
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These Rosa-STOP-mMFN mice express a Cre recombinase-inducible mutant human MFN2 containing the T105M mutation and may be useful in studies related to Charcot-Marie-Tooth neuropathy.
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| B6.129P2(Cg)-Aph1atm1Bdes Aph1btm1Bdes Aph1ctm1Bdes/J (Cat. No.: CEMM-07250838) | Inquiry | |
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These conditionally targeted Aph1abc mutant mice possess loxP sites flanking exon 2 through exon 7 of the Aph1a gene, a knock-out allele of the Aph1b gene and loxP sites flanking exons 3 and 4 of the Aph1c gene. This strain may be useful for generating conditional mutations in applications related to neurodegeneration and Alzheimer's disease.
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| B6;129S4-Gt(ROSA)26Sortm1Sor/J (Cat. No.: CEMM-07250005) | Inquiry | |
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These Gt(ROSA)26Sortm1Sor targeted mutant mice carry a loxP flanked neo cassette upstream of a β-galactosidase (lacZ) sequence. Removal of the neo cassette by cre recombination results in lacZ expression in cre-expressing tissues of the offspring.
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| B6.129S4-Psen1tm2Shn/J (Cat. No.: CEMM-07250020) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 2 and 3 of the Psen1 gene. This strain may be useful for generating conditional mutations in applications related to Alzheimer's disease.
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For Research Use Only.