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B6(Cg)-Chrna7tm1.1Ehs/YakelJ
Cat. No.: CEMM-07250627
Common Name: α7nAChRflox
α7nAChRflox mice have loxP sites flanking exon 4 of the Chrna7 gene. This strain may be useful for generating conditional mutations in studies of possible therapeutic targets for cognitive defects and applications related to the cholinergic anti-inflammatory pathway. This floxed allele acts as a hypomorph - see Detailed Description for more information.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Chrna7tm1.1Ehs
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Chrna7
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| Gene Name |
cholinergic receptor
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| Chromosome |
7
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6NTac
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| Molecular Note |
The targeting vector contains a loxP site 290 bp upstream of exon 4 and loxP site followed by a FRT flanked PGK-Neo selection cassette 380 bp downstream of exon 4. Flp-mediated recombination removed the FRT flanked neo cassette leaving exon 4 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as heterozygotes. Homozygous mice exhibit decreased breeding performance.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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