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B6.129S4-Psen1tm2Shn/J

Cat. No.: CEMM-07250020

These floxed mutant mice possess loxP sites flanking exons 2 and 3 of the Psen1 gene. This strain may be useful for generating conditional mutations in applications related to Alzheimer's disease.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Psen1tm2Shn
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Allele Name
targeted mutation 2
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Psen1
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Gene Name
presenilin 1
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Chromosome
12
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MGI Accession ID
2449304
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Strain of Origin
129S4/SvJae
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Molecular Note
A single loxP site was inserted into intron 1 and a loxP-flanked hygromycin and thymidine kinase selection cassette was inserted into intron 3. The drug selection cassette was removed in ES cells by transient Cre expression in ES cells prior to the production of mice. The final allele has single loxP sites flanking exons 2 and 3.
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HUSBANDRY
Suggested Controls
C57BL/6J
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Breeding Considerations
When maintaining a live colony, these mice can be bred as homozygotes.
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For Research Use Only.
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