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B6(C3)-Trem2tm1c(EUCOMM)Wtsi/AdiujJ
Cat. No.: CEMM-07250765
Common Name: Trem2 flox
These floxed mutant mice possess loxP sites flanking exons 2 and 3 of the Trem2 gene. This strain may be useful for generating conditional mutations in applications related to Alzheimer's Disease.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Trem2tm1c(EUCOMM)Wtsi
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| Allele Name |
targeted mutation 1c
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Trem2
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| Gene Name |
triggering receptor expressed on myeloid cells 2
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| Chromosome |
17
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N-Atm1Brd
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| Molecular Note |
The L1L2_Bact_P cassette was inserted at position 48236393 of Chromosome 17 upstream of exon 2 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted upstream of exon 4 at position 48237757. A "conditional ready" (floxed) allele is Created by flp recombinase expression in mice carrying this allele.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as heterozygotes or homozygotes. The donating investigator reports that homozygotes are viable and fertile.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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