B6;129P-Tg(Neurog1-cre/ERT2)1Good/J

Cat. No.: CEMM-07250114

When these Ngn1-CreERT2 transgenic mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Neurog1 expressing cells such as neurons in the cortex, hippocampus, thalamus, hypothalamus and the cochlear-vestibular ganglion. This mutant mouse strain may be useful for studying neuron development and lineage mapping of Neurog1 expressing cells.

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Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Neurog1-cre/ERT2)1Good show more close
Allele Name	transgene insertion 1 show more close
Allele Attributes	Recombinase-expressing; Inducible show more close
Gene Symbol	Tg(Neurog1-cre/ERT2)1Good show more close
Gene Name	transgene insertion 1 show more close
Chromosome	UN show more close
Expressed Genes	Cre, Cre recombinase, bacteriophage P1; ESR1, estrogen receptor 1, human show more close
MGI Accession ID	3777275 show more close
Site of Expression	Cre is expressed in neurons in the cortex, hippocampus, thalamus, hypothalamus and the cochlear-vestibular ganglion. show more close
Strain of Origin	C57BL/6 show more close
Molecular Note	A transgene was constructed where Cre recombinase fused to the ligand-binding domain of a mutant human estrogen receptor was placed under the control of the upstream promoter and the downstream untranslated region of the Neurog1 gene. Cre activity was detected in cochlear ganglion neurons of transgenic mice when crossed with a Cre-reporter strain and dosing with tamoxifen. show more close

HUSBANDRY
Suggested Controls	Noncarrier show more close
Breeding Considerations	When maintaining a live colony, these mice can be bred as hemizygotes. The Donating Investigator reports that homozygotes are not viable. show more close

For Research Use Only.