Online Inquiry
C57BL/6-Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple/J
Cat. No.: CEMM-07250560
Common Name: Rosa-STOP-mMFN
These Rosa-STOP-mMFN mice express a Cre recombinase-inducible mutant human MFN2 containing the T105M mutation and may be useful in studies related to Charcot-Marie-Tooth neuropathy.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Inserted expressed sequence; Humanized sequence; No functional change
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
MFN2, mitofusin 2, human
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6
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| Molecular Note |
A targeting vector containing a floxed STOP-NEO cassette, a human MFN2 cDNA carrying the T105M mutation, and human growth hormone poly A sequences under the control of the CAG promoter is inserted into the Gt(ROSA)26Sor locus.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
When maintaining a live colony, these mice can be bred as heterozygotes. The Donating Investigator has not attempted to make the strain homozygous.
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| Breeding Strategy |
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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