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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129S2(Cg)-Grin1tm1Yql/NkzaJ (Cat. No.: CEMM-07251056) | Inquiry | |
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These NMDAR1-loxP mice possess loxP sites flanking exons 9-10 of the Grin1 gene. These mice may be useful in studying the NMDAR and its downstream signaling molecules/pathways, synaptic plasticity, and social behavior.
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| B6.129(Cg)-Scn10atm2(cre)Jwo/TjpJ (Cat. No.: CEMM-07251063) | Inquiry | |
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Nav1.8-Cre knock-in/knock-out mice carry Cre recombinase under the control of the Scn10a (sodium channel, voltage-gated, type X, alpha or Nav1.8) promoter. Cre expression is observed beginning at E14 in small diameter neurons in dorsal root, trigeminal and nodose ganglia. Mice heterozygous for the mutation can be used as a tool in pain behavior studies to delete floxed genes only in nociceptors.
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| STOCK Apptm1Tlyp/Mmjax (Cat. No.: CEMM-07250879) | Inquiry | |
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Appflox conditional knock-out mice possess loxP sites flanking exon 3 of the amyloid beta (A4) precursor protein gene (App). They may be useful for studying APP function with tissue-specific and/or temporal control of APP expression.
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| STOCK Gt(ROSA)26Sortm1(CAG-cas9*, -BFP)Khk/Mmjax (Cat. No.: CEMM-07250893) | Inquiry | |
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Removal of this mouse colony is imminent. If live mice are needed for your studies, it is advised that they be ordered immediately. After removal, the mice will be available from a cryorecovery.Rosa26-LSL-dCas9 mice (Gt(ROSA)26Sortm1(CAG-dCas9-SunTag)Khk) are a Cre-inducible CRISPR/Cas9 activation (CRISPRa) tool for cell type specific gene activation in vivo.
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| C57BL/6J-Akt3em1Shzb/Mmjax (Cat. No.: CEMM-07250961) | Inquiry | |
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Akt3fl conditional knock-out mice have loxP sites flanking exon 3 of the thymoma viral proto-oncogene 3 gene. These mice may be useful for studying the role of AKT3 signaling in inflammatory demyelinating disease.
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| B6.129X1-Ntrk2tm1Lfr/RujfMmjax (Cat. No.: CEMM-07250971) | Inquiry | |
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fBZ conditional reporter/knock-out mice possess loxP sites flanking exon S of the Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2) gene and post-cre recombination expression of a tau-lacZ reporter. This strain may be useful for studying synaptic plasticity in the hippocampus.
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| C57BL/6-Marckstm2.1Pjb/J (Cat. No.: CEMM-07250987) | Inquiry | |
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MARCKSF mutant mice possess loxP sites flanking exon 2 of the Marcks (myristoylated alanine rich protein kinase C substrate) gene and may be useful in generating conditional mutations to study the regulation of cell permeability and secretion.
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| B6J.B6N-Gt(ROSA)26Sortm2(CAG-mNeonGreen)Xwy/J (Cat. No.: CEMM-07251016) | Inquiry | |
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MORF1 is one of a set of a Cre reporter tool strains (also including MORF3 and TIGRE-MORF) that use mononucleotide repeat frameshift (MORF) as a translation switch for cell labeling in vivo. MORF1 mice express a cre-dependent mNeonGreen fluorescent protein that is proceeded by a polycytosine repeat (C22) MORF switch under the control of a CAG promoter. Cre recombination combined with a spontaneous frameshift results in sparse and stochastic labeling of neural cells.
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| C57BL/6-Gt(ROSA)26Sortm3(CAG-sfGFP*)Xwy/J (Cat. No.: CEMM-07251018) | Inquiry | |
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MORF3 is one of a set of a Cre reporter tool strains (also including MORF1 and TIGRE-MORF) that use mononucleotide repeat frameshift (MORF) as a translation switch for cell labeling in vivo. MORF3 mice express a cre-dependent tandem "spaghetti monster" fluorescent protein with 20 V5 epitopes (smFP-V5) that is proceeded by a polycytosine repeat (C22) MORF switch under the control of a CAG promoter. Cre recombination combined with a spontaneous frameshift results in sparse and stochastic labeling of neural cells. MORF3 is a multivalent immunoreporter that can be used for sparse labeling of Cre+ neuronal and glial cells.
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| B6;129S-Igs7tm166(tetO-EGFP*, CAG-tTA2)Hze/XwyJ (Cat. No.: CEMM-07251019) | Inquiry | |
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TIGRE-MORF(Ai166) is one of a set of a Cre reporter tool strains (also including MORF1 and MORF3) that use mononucleotide repeat frameshift (MORF) as a translation switch for cell labeling in vivo. TIGER-MORF (Ai166) mice express a cre-dependent tetracycline-activated EGFP fluorescent protein that is proceeded by a polyguanine repeat (G22) MORF switch. Exposure to Cre recombinase removes both STOP cassettes unblocking EGFP fluorescence and tTA2 expression and in the presence of spontaneous frameshift the EGFP reporter provides sparse and stochastic labeling of neural cells. In addition, reporter expression may be diminished/eliminated by doxycycline. TIGER-MORF(Ai166) can be used for high level direct fluorescent sparse labeling of Cre+ neuronal and glial cells.
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For Research Use Only.