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STOCK Apptm1Tlyp/Mmjax
Cat. No.: CEMM-07250879
Appflox conditional knock-out mice possess loxP sites flanking exon 3 of the amyloid beta (A4) precursor protein gene (App). They may be useful for studying APP function with tissue-specific and/or temporal control of APP expression.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Apptm1Tlyp
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
App
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| Gene Name |
amyloid beta (A4) precursor protein
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| Chromosome |
16
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
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| Molecular Note |
A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, these mice are bred by homozygote sibling matings.
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| Breeding Strategy |
C57BL/6J x Heterozygote; Heterozygote x C57BL/6J
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For Research Use Only.
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